According to news reporting originating in New York City, New York, by VerticalNews journalists, research stated, "Food allergies are increasing in prevalence at a higher rate than can be explained by genetic factors, suggesting a role for as yet unidentified environmental factors. In this review, we summarize the state of knowledge about the healthy immune response to antigens in the diet and the basis of immune deviation that results in immunoglobulin E (IgE) sensitization and allergic reactivity to foods."
The news reporters obtained a quote from the research from Jaffe Food Allergy Institute, "The intestinal epithelium forms the interface between the external environment and the mucosal immune system, and emerging data suggest that the interaction between intestinal epithelial cells and mucosal dendritic cells is of particular importance in determining the outcome of immune responses to dietary antigens.
Exposure to food allergens through non-oral routes, in particular through the skin, is increasingly recognized as a potentially important factor in the increasing rate of food allergy. There are many open questions on the role of environmental factors, such as dietary factors and microbiota, in the development of food allergy, but data suggest that both have an important modulatory effect on the mucosal immune system. Finally, we discuss recent developments in our understanding of immune mechanisms of clinical manifestations of food allergy."
According to the news reporters, the research concluded: "New experimental tools, particularly in the field of genomics and the microbiome, are likely to shed light on factors responsible for the growing clinical problem of food allergy."
For more information on this research see: Mucosal Immunology of Food Allergy. Current Biology, 2013;23(9):R389-R400. Current Biology can be contacted at: Cell Press, 600 Technology Square, 5TH Floor, Cambridge, MA 02139, USA. (Elsevier - www.elsevier.com; Current Biology - www.elsevier.com/wps/product/cws_home/601284)
Our news correspondents report that additional information may be obtained by contacting M.C. Berin, Icahn Sch Med Mt Sinai, Dept. of Pediat, Jaffe Food Allergy Inst, New York, NY, United States.
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